Urinating Frequently at Night times | Causes and Treatment of Frequent Urinating at night Night

Urinating frequently at night times can be very uncomfortable and stressful. All you want is a good sleep. But you body keeps producing more urine at night times. Normally, the amount of urine your body produces decreases at night. This allows most people to sleep 6 to 8 hours without having to urinate.

Urinating Frequently at Night times | Causes and Treatment of Frequent Urinating at night Night
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Some people wake up from sleep more often to urinate during the night, and this can disrupt sleep cycles.

Causes of Urinating frequently at night times

Drinking too much fluid during the evening can be regarded as one of the major causes of Urinating Frequently at Night times. Caffeine and alcohol after dinner can also lead to this problem. some of the major causes of this problem are;

  • Infection of the bladder or urinary tract
  • Drinking a lot of alcohol, caffeine, or other fluids before bedtime
  • Enlarged prostate gland (benign prostatic hyperplasia, BPH)
  • Pregnancy

People who live with certain health conditions are also known to suffer frequent urinating which in some cases may not only be at night times. some of these health conditions include;

  • Chronic kidney failure
  • Diabetes
  • Drinking excessive amount of water
  • Heart failure
  • High blood calcium level
  • Certain medicines, including water pills (diuretics)
  • Diabetes insipidus
  • Swelling of the legs

Waking often during the night to urinate can also be linked to obstructive sleep apnea and other sleeping disorders. Nocturia may go away when the sleeping problem is under control. Stress and restlessness can also cause you to wake up at night.

First treatment for frequent urinating at night due to overproduction of urine as approved by the FDA

The U.S. Food and Drug Administration has approved Noctiva (desmopressin acetate) nasal spray for adults who awaken at least two times per night to urinate due to a condition known as nocturnal polyuria (overproduction of urine during the night). Noctiva is the first FDA-approved treatment for this condition.

Hylton V. Joffe, M.D., M.Sc.., director of the Division of Bone, Reproductive, and Urologic Products in the FDA’s Center for Drug Evaluation and Research said “The approval of this treatment option provides adults who overproduce urine at night with the first FDA-approved therapeutic option to help reduce the number of times a night they wake up to urinate.

It is important to know that Noctiva is not approved for all causes of Urinating Frequently at Night times, so patients should discuss their symptoms with their health care provider who can determine the underlying cause of the night-time urination and whether Noctiva is right for them.”

Nocturia (wakening at night to urinate) is a symptom that can be caused by a wide variety of conditions, such as congestive heart failure, poorly controlled diabetes mellitus, medications, or diseases of the bladder or prostate.

Before considering Noctiva, health care providers should evaluate each patient for possible causes for the Nocturia, and optimize the treatment of underlying conditions that may be contributing to the health issue of urinating frequently at night times.

Because Noctiva is approved only for adults with Nocturia ailment, which is caused by nocturnal polyuria, health care providers should confirm overproduction of urine at night with a 24-hour urine collection, if one has not been obtained previously. Health care providers should also be mindful of underlying conditions that can cause Nocturia, but that make treatment with Noctiva unsafe, such as excessive drinking of fluids or symptomatic congestive heart failure.

Noctiva is taken daily, approximately 30 minutes before going to bed. It works by increasing the absorption of water through the kidneys, which leads to less urine production. The efficacy of Noctiva was established in two 12-week, randomized, placebo-controlled trials in 1,045 patients 50 years of age and older with Nocturia due to nocturnal polyuria.

Although these trials showed a small reduction in the average number of night-time urinations with Noctiva compared to placebo, more patients treated with Noctiva were able to at least halve their number of night-time urinations, and patients treated with Noctiva had more nights with one or fewer night-time urinations.

Noctiva is being approved with a boxed warning and a Medication Guide because it can cause low sodium levels in the blood (hyponatremia). Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated, leading to seizures, coma, respiratory arrest or death. Health care providers should make sure the patient’s sodium level is normal before starting Noctiva, and should check sodium levels within one week and approximately one month after starting treatment and periodically thereafter.

The lower Noctiva dose is recommended as the starting dose for those who may be at risk for hyponatremia, such as the elderly. Noctiva should not be used in patients at increased risk of severe hyponatremia, such as those with excessive fluid intake, those who have illnesses that can cause fluid or electrolyte imbalances, certain patients with kidney damage, and in those using certain medicines, known as loop diuretics or glucocorticoids.

Noctiva should also not be used in patients with symptomatic congestive heart failure or uncontrolled hypertension because fluid retention can worsen these underlying conditions. Use of Noctiva should be discontinued temporarily in patients with certain nasal conditions such as colds or allergies until those conditions have resolved.

Noctiva is also not recommended for the treatment of Nocturia in pregnant women. Nocturia is usually related to normal changes in pregnancy that do not require treatment with Noctiva. Noctiva should not be used in children.

The most common side effects of Noctiva in clinical trials included nasal discomfort, cold symptoms (nasopharyngitis), nasal congestion, sneezing, high or increased blood pressure, back pain, nose bleeds, bronchitis and dizziness.

Although there are other FDA-approved medications that also contain desmopressin, none of those medications are approved to treat Nocturia.

Noctiva is manufactured by Renaissance Lakewood, LLC for Milford, Pennsylvania-based Serenity Pharmaceuticals, LLC.

The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The Agency also is responsible for the safety and security of our nation’s food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.

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